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Ep300tm3Pkb
Targeted Allele Detail
Nomenclature
Symbol: Ep300tm3Pkb
Name: E1A binding protein p300; targeted mutation 3, Paul K Brindle
MGI ID: MGI:3612049
Synonyms: p300deltaCH1
Gene: Ep300  Location: Chr15:81585351-81652072 bp, + strand  Genetic Position: Chr15, 38.16 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:103607
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted
Mutation:    Intragenic deletion
 
Mutation detailsPortions of the CH1 domain (amino acids 329-379) encoded by exon 4 were deleted and a neomycin resistance cassette flanked by FRT sites was introduced to the downstream intron. Transient infection of the ES cells with a Flp-expressing vector excised the neomycin cassette. RT-PCR confirmed the deletion in mutant MEFs. (J:103607)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ep300 Mutation:  26 strains or lines available
References
Original:  J:103607 Kasper LH, et al., Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression. EMBO J. 2005 Nov 16;24(22):3846-58
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory