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Targeted Allele Detail
Symbol: Crebbptm2Pkb
Name: CREB binding protein; targeted mutation 2, Paul K Brindle
MGI ID: MGI:3612048
Synonyms: CBPdeltaCH1
Gene: Crebbp  Location: Chr16:4081334-4213957 bp, - strand  Genetic Position: Chr16, 2.4 cM
Germline Transmission:  Earliest citation of germline transmission: J:103607
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsPortions of the CH1 domain (amino acids 342-393) was deleted and a neomycin resistance cassette flanked by loxp sites was introduced to the upstream intron. Transient infection of the ES cells with a Cre-expressing vector excised the neomycin cassette. RT-PCR confirmed the deletion in mutant MEFs. (J:103607)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Crebbp Mutation:  18 strains or lines available
Original:  J:103607 Kasper LH, et al., Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression. EMBO J. 2005 Nov 16;24(22):3846-58
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory