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Lsr1A/J
QTL Variant Detail
Summary
QTL variant: Lsr1A/J
Name: listeria resistance; A/J
MGI ID: MGI:3612035
QTL: Lsr1  Location: unknown  Genetic Position: Chr2, Syntenic
Variant
origin
Strain of Specimen:  A/J
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers susceptibility to infection by Listeria monocytogenes compared to C57BL/6J. (J:7345)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:7345

Analysis of 13 AXB/BXA (A=A/J; B=C57BL/6J) recombinant inbred (RI) strains mapped resistance to Listeria monocytogenes to mouse Chromosome 2 near the Hc locus (23.5 cM). This locus is named Lsr1 (listeria resistance 1). Parental strain A/J is susceptibleto L. monocytogenes whereas parental strain C57BL/6J is resistant. The A/J-derived allele at Lsr1 confers susceptibility to L. monocytogenes and the C57BL/6J-derived allele at Lsr1 confers resistance. A second yet unmapped modifyier locus is believed to exist.

Interestingly, A/J and all of the susceptible AXB/BXA RI strains are deficient for hemolytic complement C5 encoded by Hc. Infusion of C5 into the serum of susceptible strain A/J conferred protection agains L. monocytogenes.

References
Original:  J:7345 Gervais F, et al., Genetic control of resistance to Listeria monocytogenes: regulation of leukocyte inflammatory responses by the Hc locus. J Immunol. 1984 Apr;132(4):2078-83
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory