Smarcb1^tm2Mya
Targeted Allele Detail

Summary

• Symbol: Smarcb1^tm2Mya
• Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1; targeted mutation 2, Moshe Yaniv
• MGI ID: MGI:3611918
• Synonyms: SNF5^flox
• Gene: Smarcb1 Location: Chr10:75732603-75757448 bp, - strand Genetic Position: Chr10, 38.61 cM
• Alliance: Smarcb1^tm2Mya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103919
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank exons 1 and 2 of the locus. Cre-mediated recombination would result in the deletion of sequence including the initiation ATG, and thereby generate a null allele. (J:103919)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smarcb1 Mutation: 22 strains or lines available

References

• Original: J:103919 Gresh L, et al., The SWI/SNF chromatin-remodeling complex subunit SNF5 is essential for hepatocyte differentiation. EMBO J. 2005 Sep 21;24(18):3313-24
• All: 7 reference(s)