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Targeted Allele Detail
Symbol: Kcnk3tm1Sgb
Name: potassium channel, subfamily K, member 3; targeted mutation 1, Stephen G Brickley
MGI ID: MGI:3611768
Synonyms: TASK-1 -
Gene: Kcnk3  Location: Chr5:30588170-30625270 bp, + strand  Genetic Position: Chr5, 16.68 cM, cytoband B
Germline Transmission:  Earliest citation of germline transmission: J:103747
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 1, encoding the first transmembrane domain through the beginning of the first P1 loop was disrupted by homologous recombination. An IRES-lacZ-SV40pA-neo cassette containing a stop codon in all three reading frames replaced the first 21 amino acids. In situ hybridization and real time PCR showed that the targeted allele is not expressed in either mutant brain or heart samples. (J:103747)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kcnk3 Mutation:  22 strains or lines available
Phenotypic Similarity to Human Syndrome: Primary aldosteronism in homozygous mice (J:188335)
Original:  J:103747 Aller MI, et al., Modifying the subunit composition of TASK channels alters the modulation of a leak conductance in cerebellar granule neurons. J Neurosci. 2005 Dec 7;25(49):11455-67
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory