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Postntm1Sjc
Targeted Allele Detail
Nomenclature
Symbol: Postntm1Sjc
Name: periostin, osteoblast specific factor; targeted mutation 1, Simon J Conway
MGI ID: MGI:3611751
Synonyms: PerilacZ, periostin-, Postn-, PostnLacZ
Gene: Postn  Location: Chr3:54361109-54391034 bp, + strand  Genetic Position: Chr3, 25.46 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:103753
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA promoterless IRES-lacZ-neo-loxP cassette replaced the translation start site and all of the first exon and about 300 bp of the first intron. Western blot analysis failed to detect protein in newborn mutants. Whole-embryo staining showed widespread expression, particularly within the peripheral nervous system, craniofacial region, dermis of the skin, and body cavities. (J:103753)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 6 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Postn Mutation:  3 strains or lines available
Notes

Phenotypic Similarity to Human Syndrome: Systemic and Jaw Osteopenia J:200192

References
Original:  J:103753 Rios H, et al., periostin null mice exhibit dwarfism, incisor enamel defects, and an early-onset periodontal disease-like phenotype. Mol Cell Biol. 2005 Dec;25(24):11131-44
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/21/2015
MGI 5.21
The Jackson Laboratory