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Rxrbtm1Pcn
Targeted Allele Detail
Nomenclature
Symbol: Rxrbtm1Pcn
Name: retinoid X receptor beta; targeted mutation 1, Pierre Chambon
MGI ID: MGI:3611570
Synonyms: RXRbetaL2
Gene: Rxrb  Location: Chr17:34031812-34038393 bp, + strand  Genetic Position: Chr17, 17.98 cM
Rxratm4Ipc/Rxratm4Ipc Rxrbtm1Pcn/Rxrbtm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0 mice develop a chronic skin inflammation

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:102470
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
    LoxP sites flank exons 3 and 4, which encode the B and C regions and the Nt amino acids of region D. (J:102470, J:109510)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rxrb Mutation:  2 strains or lines available
References
Original:  J:102470 Li M, et al., Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin. Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14795-800
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory