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QTL Variant Detail
QTL variant: Carg2C57L/J
Name: Candida albicans resistance gene 2; C57L/J
MGI ID: MGI:3611482
QTL: Carg2  Location: unknown  
Strain of Specimen:  C57L/J
Allele Type:    QTL

Mapping and Phenotype information for this QTL, its variants and associated markers


The strain distribution patterns (SDPs) in 15 AKXL (AKR/J x C57L/J) RI strains suggest that at least two gene families facilitate the tissue damage caused by systemic infection of Candida albicans. One of these genes has been designated as Carg2. The SDPs of this locus, Carg2 does not significantly correlate with any known genetic marker currently mapped in the AKXL set.

The parental strain AKR/J exhibits greater susceptibility to infection by C. albicans compared to parental strain C57L/J.

Original:  J:39424 Ashman RB, et al., Evidence that two independent host genes influence the severity of tissue damage and susceptibility to acute pyelonephritis in murine systemic candidiasis. Microb Pathog. 1997 Mar;22(3):187-92
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.20
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