Grin1^tm1Rsp
Targeted Allele Detail

Summary

• Symbol: Grin1^tm1Rsp
• Name: glutamate receptor, ionotropic, NMDA1 (zeta 1); targeted mutation 1, Rolf Sprengel
• MGI ID: MGI:3611337
• Synonyms: GluN1^2lox, NR1^f
• Gene: Grin1 Location: Chr2:25181193-25209199 bp, - strand Genetic Position: Chr2, 17.14 cM
• Alliance: Grin1^tm1Rsp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103818
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites have been inserted flanking the region including exons 11 through 18. In addition 4 silent mutations corresponding to the homologous rat sequence were introduced into the 4 adjacent codons that encode part of the M1 segment in exon 14. (J:103818, J:119834)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grin1 Mutation: 64 strains or lines available

References

• Original: J:103818 Shimshek DR, et al., Impaired reproductive behavior by lack of GluR-B containing AMPA receptors but not of NMDA receptors in hypothalamic and septal neurons. Mol Endocrinol. 2006 Jan;20(1):219-31
• All: 29 reference(s)