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Sorbs3tm1Kmor
Targeted Allele Detail
Nomenclature
Symbol: Sorbs3tm1Kmor
Name: sorbin and SH3 domain containing 3; targeted mutation 1, Ken-ichirou Morohashi
MGI ID: MGI:3611214
Synonyms: Vinexin gamma-
Gene: Sorbs3  Location: Chr14:70417917-70449438 bp, - strand  Genetic Position: Chr14, 36.27 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:102860
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (Modified isoform(s))
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gamma-form specific first exon was deleted along with the upstream region upon the insertion of a PGK-neo-pA cassette. Fetal gonads were analyzed by western blot to confirm absence of the gamma and alpha isoforms. The beta isoform is still expressed. (J:102860)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sorbs3 Mutation:  25 strains or lines available
References
Original:  J:102860 Matsuyama M, et al., A novel isoform of Vinexin, Vinexin gamma, regulates Sox9 gene expression through activation of MAPK cascade in mouse fetal gonad. Genes Cells. 2005 May;10(5):421-34
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/27/2022
MGI 6.21
The Jackson Laboratory