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Loxtm1Soin
Targeted Allele Detail
Nomenclature
Symbol: Loxtm1Soin
Name: lysyl oxidase; targeted mutation 1, Raija Soininen
MGI ID: MGI:3610732
Synonyms: Lox-
Gene: Lox  Location: Chr18:52516069-52529867 bp, - strand  Genetic Position: Chr18, 28.22 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:103389
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsCre mediated recombination was used to excise exon 1, from about 600 bp upstream of the translation start codon to about 90 bp downstream of exon 1. Northern blot confirmed complete inactivation of the gene. (J:103389)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lox Mutation:  9 strains or lines available
References
Original:  J:103389 Maki JM, et al., Inactivation of the lysyl oxidase gene Lox leads to aortic aneurysms, cardiovascular dysfunction, and perinatal death in mice. Circulation. 2002 Nov 5;106(19):2503-9
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory