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Cbltm2Wlan
Targeted Allele Detail
Summary
Symbol: Cbltm2Wlan
Name: Casitas B-lineage lymphoma; targeted mutation 2, Wallace Y Langdon
MGI ID: MGI:3610727
Synonyms: A, c-CblA, c-Cbl(C379A)
Gene: Cbl  Location: Chr9:44054273-44145346 bp, - strand  Genetic Position: Chr9, 24.72 cM
Alliance: Cbltm2Wlan page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:103366
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsA point mutation resulted in a cysteine to alanine substitution at position 379 (C379A). Western blot showed that protein levels in thymocytes were not affected by the mutation. (J:103366)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 13 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Cbl Mutation:  57 strains or lines available
References
Original:  J:103366 Thien CB, et al., Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion. EMBO J. 2005 Nov 2;24(21):3807-19
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory