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Abcb1btm1Bor
Targeted Allele Detail
Nomenclature
Symbol: Abcb1btm1Bor
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 1B; targeted mutation 1, Piet Borst
MGI ID: MGI:3610191
Synonyms: mdr1a/1b-, Mdr1a/b-
Gene: Abcb1b  Location: Chr5:8798147-8866314 bp, + strand  Genetic Position: Chr5, 3.43 cM, cytoband A2-A3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:39804
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsES cells containing a previously targeted Abcb1a allele (Abcb1atm1Bor) were targeted again with a vector replacing exons 3 and 4 of Abcb1b with a neomycin selection cassette. The vector contained a MluI linker 3' of the neo cassette that allowed detection of the Abcb1b disruption linked to the previous Abcb1a disruption by long-range restriction mapping. (J:39804)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Abcb1b Mutation:  15 strains or lines available
References
Original:  J:39804 Schinkel AH, et al., Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins. Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):4028-33
All:  55 reference(s)

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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory