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Targeted Allele Detail
Symbol: Adamts1tm1Mlia
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1; targeted mutation 1, M Luisa Iruela-Arispe
MGI ID: MGI:3609982
Gene: Adamts1  Location: Chr16:85590715-85600001 bp, - strand  Genetic Position: Chr16, 48.2 cM, cytoband C3-C5
Germline Transmission:  Earliest citation of germline transmission: J:102464
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector was used to replace exons 2-8 with a loxP flanked neomycin resistance cassette. Fluorescence immunohistochemical analysis failed to detect protein in mutant. (J:102464)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 7 assay results
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adamts1 Mutation:  41 strains or lines available
Original:  J:102464 Lee NV, et al., Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1. J Biol Chem. 2005 Oct 14;280(41):34796-804
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory