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Targeted Allele Detail
Symbol: Nt5etm1Jsc
Name: 5' nucleotidase, ecto; targeted mutation 1, Jurgen Schrader
MGI ID: MGI:3609975
Synonyms: Cd73-
Gene: Nt5e  Location: Chr9:88327197-88372092 bp, + strand  Genetic Position: Chr9, 47.24 cM, cytoband E3.2
Germline Transmission:  Earliest citation of germline transmission: J:102299
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsExon 2 was deleted via cre-mediated excision. RT-PCR detected a shortened transcript at levels similar to wild-type. The mutation caused a frame shift at the new exon 1 to 3 junction, resulting in the termination of translation after the first exon. Protein was not detected in Western blot. (J:102299)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nt5e Mutation:  10 strains or lines available
Original:  J:102299 Koszalka P, et al., Targeted disruption of cd73/ecto-5'-nucleotidase alters thromboregulation and augments vascular inflammatory response. Circ Res. 2004 Oct 15;95(8):814-21
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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