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Casp2tm1Vaux
Targeted Allele Detail
Nomenclature
Symbol: Casp2tm1Vaux
Name: caspase 2; targeted mutation 1, David L Vaux
MGI ID: MGI:3609949
Synonyms: Casp2-
Gene: Casp2  Location: Chr6:42264985-42282508 bp, + strand  Genetic Position: Chr6, 20.54 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:103480
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 1.65 kb genomic fragment containing sequences that encode part of the active site of the protein and other essential regions was replaced via homologous recombination with a neomycin resistance cassette in forward orientation. (J:103480)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Casp2 Mutation:  8 strains or lines available
References
Original:  J:103480 O'Reilly LA, et al., Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9. Cell Death Differ. 2002 Aug;9(8):832-41
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory