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Targeted Allele Detail
Symbol: Sgcgtm1Oza
Name: sarcoglycan, gamma (dystrophin-associated glycoprotein); targeted mutation 1, Eijiro Ozawa
MGI ID: MGI:3609567
Synonyms: gsg-
Gene: Sgcg  Location: Chr14:61221059-61258490 bp, - strand  Genetic Position: Chr14, 32.27 cM, cytoband C3
Germline Transmission:  Earliest citation of germline transmission: J:102780
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance gene replaced exon 3, which encodes the translation initiation site, the cytoplasmic domain, and the transmembrane domain of the encoded protein. Immunoblot analysis detected markedly reduced expression of alpha, beta and delta subunits and complete lack of the gamma subunit. (J:102780)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sgcg Mutation:  1 strain or line available
Original:  J:102780 Sasaoka T, et al., Pathological analysis of muscle hypertrophy and degeneration in muscular dystrophy in gamma-sarcoglycan-deficient mice. Neuromuscul Disord. 2003 Mar;13(3):193-206
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.21
The Jackson Laboratory