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Targeted Allele Detail
Symbol: Admtm1Tfjt
Name: adrenomedullin; targeted mutation 1, Toshiro Fujita
MGI ID: MGI:3609557
Synonyms: AdmAM, AM-
Gene: Adm  Location: Chr7:110627661-110629820 bp, + strand  Genetic Position: Chr7, 57.7 cM
Germline Transmission:  Earliest citation of germline transmission: J:102946
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsA targeting vector was designed to insert a stop mutation at the beginning of the coding region at exon 4. A floxed tk-neo was included in the vector to be inserted into intron 1. The disruption was confirmed by the absence of immunoreactive protein in the mutant fetus. (J:102946)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adm Mutation:  7 strains or lines available
Original:  J:102946 Shimosawa T, et al., Adrenomedullin, an endogenous peptide, counteracts cardiovascular damage. Circulation. 2002 Jan 1;105(1):106-11
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
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