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Apptm1Ck
Targeted Allele Detail
Nomenclature
Symbol: Apptm1Ck
Name: amyloid beta (A4) precursor protein; targeted mutation 1, Christoph Kohler
MGI ID: MGI:3609234
Synonyms: APP/hAbeta, APP-SL, APPsl/Abeta
Gene: App  Location: Chr16:84952666-85173952 bp, - strand  Genetic Position: Chr16, 46.92 cM, cytoband C3-qter
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:102542
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Humanized sequence)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed such that the locus contains the Swedish/London-FAD mutation and a "humanized" Abeta domain sequence in exons 16-18 under the control of the endogenouse APP promoter. A pA sequence and neomycin resistance gene was included in the vector. (J:102542)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any App Mutation:  16 strains or lines available
Notes
ES cell line = G1 (Bayer), established from an unspecified 129 subline.
References
Original:  J:102542 Kohler C, et al., Alzheimer's disease-like neuropathology of gene-targeted APP-SLxPS1mut mice expressing the amyloid precursor protein at endogenous levels. Neurobiol Dis. 2005 Nov;20(2):528-40
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/16/2018
MGI 6.12
The Jackson Laboratory