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Targeted Allele Detail
Symbol: Dsg2tm1Leu
Name: desmoglein 2; targeted mutation 1, Rudolf E Leube
MGI ID: MGI:3609221
Synonyms: Dsg2-
Gene: Dsg2  Location: Chr18:20558074-20604521 bp, + strand  Genetic Position: Chr18, 11.42 cM
Germline Transmission:  Earliest citation of germline transmission: J:102536
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting construct was designed to replace exons 7 and 8 with a lacZ and neo cassette. The putative transcript would have a dysfunctional aminoterminal fragment, terminating in the extracellular E2 domain at a position that corresponds to amino acid 229 of the human transcript. (J:102536)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dsg2 Mutation:  43 strains or lines available
Original:  J:102536 Eshkind L, et al., Loss of desmoglein 2 suggests essential functions for early embryonic development and proliferation of embryonal stem cells. Eur J Cell Biol. 2002 Nov;81(11):592-8
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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