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Prkcetm1Bsca
Targeted Allele Detail
Nomenclature
Symbol: Prkcetm1Bsca
Name: protein kinase C, epsilon; targeted mutation 1, Lisardo Bosca
MGI ID: MGI:3609215
Synonyms: PKCepsilon-
Gene: Prkce  Location: Chr17:86167785-86657919 bp, + strand  Genetic Position: Chr17, 56.74 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:103337
Parent Cell Line:  GK129 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to insert stop codons in all three reading frames, an IRES-lacZ-pA and a neomycin resistance gene into exon 1. Northern and Western blot analyses confirmed that transcript and protein were absent in mutants. (J:103337)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prkce Mutation:  6 strains or lines available
References
Original:  J:103337 Castrillo A, et al., Protein kinase Cepsilon is required for macrophage activation and defense against bacterial infection. J Exp Med. 2001 Nov 5;194(9):1231-42
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory