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Targeted Allele Detail
Symbol: Mertktm1Lex
Name: c-mer proto-oncogene tyrosine kinase; targeted mutation 1, Lexicon Genetics
MGI ID: MGI:3609164
Synonyms: mer-
Gene: Mertk  Location: Chr2:128698956-128802894 bp, + strand  Genetic Position: Chr2, 62.63 cM
Germline Transmission:  Earliest citation of germline transmission: J:102333
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEvBrd
Project Collection: Lexicon
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance gene replaced 107 bp of the first coding exon containing transcription and translation start sites. Northern blot confirmed absence of transcript in mutant mice. Western blot showed absence of protein in mutant liver cell extracts. (J:102333)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mertk Mutation:  24 strains or lines available
Original:  J:102333 Chen C, et al., Mer receptor tyrosine kinase signaling participates in platelet function. Arterioscler Thromb Vasc Biol. 2004 Jun;24(6):1118-23
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
The Jackson Laboratory