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Sh3glb1tm1Hgw
Targeted Allele Detail
Nomenclature
Symbol: Sh3glb1tm1Hgw
Name: SH3-domain GRB2-like B1 (endophilin); targeted mutation 1, Hong-Gang Wang
MGI ID: MGI:3608890
Synonyms: bif-1-
Gene: Sh3glb1  Location: Chr3:144683678-144720335 bp, - strand  Genetic Position: Chr3, 69.0 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:102178
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting construct was designed to replace exon 1 and the translation start site. Immunoblots of whole cell lysates confirmed absence of protein in mutant embryos. (J:102178)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 16 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sh3glb1 Mutation:  4 strains or lines available
References
Original:  J:102178 Takahashi Y, et al., Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis. Mol Cell Biol. 2005 Nov;25(21):9369-82
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory