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Yap1tm1Smil
Targeted Allele Detail
Nomenclature
Symbol: Yap1tm1Smil
Name: yes-associated protein 1; targeted mutation 1, Sharon L Milgram
MGI ID: MGI:3608880
Synonyms: Yaptm1Smil
Gene: Yap1  Location: Chr9:7931999-8004596 bp, - strand  Genetic Position: Chr9, 2.46 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:102253
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe targeting event replaced approximately 1 kb of the gene, including the translation initiation site and all but 10 bp of exon 1, with a floxed MC1-neo cassette in reverse orientation. Western blot analysis of lysates of whole E8.5 embryos using affinity-purified antiserum to the C-terminus of human YAP protein produced no signal. (J:102253)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Yap1 Mutation:  27 strains or lines available
References
Original:  J:102253 Morin-Kensicki EM, et al., Defects in yolk sac vasculogenesis, chorioallantoic fusion, and embryonic axis elongation in mice with targeted disruption of yap65. Mol Cell Biol. 2006 Jan;26(1):77-87
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/13/2017
MGI 6.10
The Jackson Laboratory