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Targeted Allele Detail
Symbol: Gadd45btm1Daa
Name: growth arrest and DNA-damage-inducible 45 beta; targeted mutation 1, Dan A Liebermann
MGI ID: MGI:3608798
Synonyms: Gadd45b-
Gene: Gadd45b  Location: Chr10:80930091-80932204 bp, + strand  Genetic Position: Chr10, 39.72 cM
Germline Transmission:  Earliest citation of germline transmission: J:102680
Parent Cell Line:  ESVJ-1183 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation details301 bp of the proximal promoter, the 5' untranslated region of the mRNA, the entire protein coding region and 425 bp of the 3' untranslated region were replaced by a 1.9 kb neo cassette (transcription of neo is antisense) from the plasmid pGT-N29 via homologous recombination. (J:102680)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gadd45b Mutation:  2 strains or lines available
Original:  J:102680 Gupta M, et al., Hematopoietic cells from Gadd45a- and Gadd45b-deficient mice are sensitized to genotoxic-stress-induced apoptosis. Oncogene. 2005 Nov 3;24(48):7170-9
All:  6 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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