Gadd45b^tm1Daa
Targeted Allele Detail

Summary

• Symbol: Gadd45b^tm1Daa
• Name: growth arrest and DNA-damage-inducible 45 beta; targeted mutation 1, Dan A Liebermann
• MGI ID: MGI:3608798
• Synonyms: Gadd45b^-
• Gene: Gadd45b Location: Chr10:80765925-80768038 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Gadd45b^tm1Daa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102680
• Parent Cell Line: ESVJ-1183 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 301 bp of the proximal promoter, the 5' untranslated region of the mRNA, the entire protein coding region and 425 bp of the 3' untranslated region were replaced by a 1.9 kb neo cassette (transcription of neo is antisense) from the plasmid pGT-N29 via homologous recombination. (J:102680)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gadd45b Mutation: 12 strains or lines available

References

• Original: J:102680 Gupta M, et al., Hematopoietic cells from Gadd45a- and Gadd45b-deficient mice are sensitized to genotoxic-stress-induced apoptosis. Oncogene. 2005 Nov 3;24(48):7170-9
• All: 13 reference(s)