Acsm3^tm1Njs
Targeted Allele Detail

Summary

• Symbol: Acsm3^tm1Njs
• Name: acyl-CoA synthetase medium-chain family member 3; targeted mutation 1, Nilesh J Samani
• MGI ID: MGI:3608776
• Synonyms: SA-
• Gene: Acsm3 Location: Chr7:119360106-119384119 bp, + strand Genetic Position: Chr7, 64.17 cM, cytoband F3
• Alliance: Acsm3^tm1Njs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103031
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3.3 kb fragment, including exons 2 and 3, was replaced with a neo cassette via homologous recombination. Northern blot analysis detected very low levels of expression (less than 10% that of wild-type) and Western blot analysis did not detect any protein expression in the liver. (J:103031)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acsm3 Mutation: 39 strains or lines available

References

• Original: J:103031 Walsh V, et al., Analysis of the role of the SA gene in blood pressure regulation by gene targeting. Hypertension. 2003 Jun;41(6):1212-8
• All: 1 reference(s)