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Cx3cr1tm1Zm
Targeted Allele Detail
Nomenclature
Symbol: Cx3cr1tm1Zm
Name: chemokine (C-X3-C motif) receptor 1; targeted mutation 1, Ziad Mallat
MGI ID: MGI:3608773
Synonyms: CX3CR1 KO
Gene: Cx3cr1  Location: Chr9:120048683-120068296 bp, - strand  Genetic Position: Chr9, 71.37 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:103047
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 600 bp fragment, including the start codon and 382 bp of coding region, was replaced with a neo cassette via homologous recombination. (J:103047)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cx3cr1 Mutation:  29 strains or lines available
Notes
ES cell line = R1.211
References
Original:  J:103047 Combadiere C, et al., Decreased atherosclerotic lesion formation in CX3CR1/apolipoprotein E double knockout mice. Circulation. 2003 Feb 25;107(7):1009-16
All:  47 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory