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Targeted Allele Detail
Symbol: Snapintm1Zhs
Name: SNAP-associated protein; targeted mutation 1, Zu-Hang Sheng
MGI ID: MGI:3608768
Synonyms: snapin KO
Gene: Snapin  Location: Chr3:90488026-90491033 bp, - strand  Genetic Position: Chr3, 39.24 cM
Germline Transmission:  Earliest citation of germline transmission: J:102725
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAll four coding exons were replaced by a PGKneo cassette via homologous recombination. Southern blot analysis revealed a novel 5.9 kb DNA fragment corresponding to the interrupted gene, however Western blot analysis confirmed absence of protein expression. (J:102725)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Snapin Mutation:  7 strains or lines available
Original:  J:102725 Tian JH, et al., The role of Snapin in neurosecretion: snapin knock-out mice exhibit impaired calcium-dependent exocytosis of large dense-core vesicles in chromaffin cells. J Neurosci. 2005 Nov 9;25(45):10546-55
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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