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Targeted Allele Detail
Symbol: Oxtrtm1.1Knis
Name: oxytocin receptor; targeted mutation 1.1, Katsuhiko Nishimori
MGI ID: MGI:3608706
Synonyms: OTR KO
Gene: Oxtr  Location: Chr6:112473683-112489943 bp, - strand  Genetic Position: Chr6, 52.27 cM, cytoband E3
Germline Transmission:  Earliest citation of germline transmission: J:102924
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-Neo cassette was inserted into intron 3 and three loxP sites around exons 2 and 3 and the PGK-Neo. Chimeras were mated to Tg(ACTB-cre)13Miya mice to remove exons 2 and 3 and the PGK-Neo cassette. Northern blot analysis and RT-PCR confirmed absence of RNA. (J:102924)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 7 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Oxtr Mutation:  25 strains or lines available
Original:  J:102924 Takayanagi Y, et al., Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice. Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):16096-101
All:  12 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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