About   Help   FAQ
Ext2tm1Werb
Targeted Allele Detail
Nomenclature
Symbol: Ext2tm1Werb
Name: exostoses (multiple) 2; targeted mutation 1, Zena Werb
MGI ID: MGI:3608690
Gene: Ext2  Location: Chr2:93661028-93822568 bp, - strand  Genetic Position: Chr2, 51.62 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:103125
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 was replaced by a PGK-neo cassette via homologous recombination. RT-PCR and western blot analysis detected a truncated RNA and protein product in trophoblast stem cells, however heparan sulfate synthesis does not occur. (J:103125)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ext2 Mutation:  24 strains or lines available
References
Original:  J:103125 Stickens D, et al., Mice deficient in Ext2 lack heparan sulfate and develop exostoses. Development. 2005 Nov;132(22):5055-68
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/15/2018
MGI 6.12
The Jackson Laboratory