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Tg(KRT14-Kitl)1Takk
Transgene Detail
Nomenclature
Symbol: Tg(KRT14-Kitl)1Takk
Name: transgene insertion 1, Takahiro Kunisada
MGI ID: MGI:3607790
Synonyms: K14-Scf, Kitl-Tg, KRT14-Kitl, SCF-Tg, Tg(KRT14-itl)1Takk
Transgene: Tg(KRT14-Kitl)1Takk  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x SJL)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
    The human cytokeratin 14 upstream region was used to drive expression of kit ligand. (J:49253)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
(C57BL x SJL) F1 fertilized oocytes were microinjected with the vector.
Phenotypic Similarity to Human Syndrome: Cutaneous Malignant Melanoma in mice hemizygous for this transgene and homozygous for this allele Xpatm1Tnka

References
Original:  J:49253 Kunisada T, et al., Transgene expression of steel factor in the basal layer of epidermis promotes survival, proliferation, differentiation and migration of melanocyte precursors. Development. 1998 Aug;125(15):2915-23
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory