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Targeted Allele Detail
Symbol: Clip1tm1Gal
Name: CAP-GLY domain containing linker protein 1; targeted mutation 1, Niels Galjart
MGI ID: MGI:3607145
Synonyms: CLIP-170 KO
Gene: Clip1  Location: Chr5:123577795-123684618 bp, - strand  Genetic Position: Chr5, 63.06 cM
Germline Transmission:  Earliest citation of germline transmission: J:102107
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Hypomorph)
Mutation:    Insertion
Mutation detailsA GFP-loxP-pMC1neo-loxP cassette was inserted in front of the ATG in exon 2. The neo is in antisense orientation. Northern blot demonstrated the lack of mRNA in brain, heart, skeletal muscle, MEFs and testis; however, transcript was detected in lung and embryonic extracts, indicating the allele is a hypomorph. The testis specific isoform was not affected by the targeting event, and was expressed in mutants. (J:102107)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Clip1 Mutation:  24 strains or lines available
Original:  J:102107 Akhmanova A, et al., The microtubule plus-end-tracking protein CLIP-170 associates with the spermatid manchette and is essential for spermatogenesis. Genes Dev. 2005 Oct 15;19(20):2501-15
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
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