Acadvl^tm1Vje
Targeted Allele Detail

Summary

• Symbol: Acadvl^tm1Vje
• Name: acyl-Coenzyme A dehydrogenase, very long chain; targeted mutation 1, Vernat J Exil
• MGI ID: MGI:3606688
• Synonyms: VLCAD^-, VLCADD
• Gene: Acadvl Location: Chr11:69901009-69906237 bp, - strand Genetic Position: Chr11, 42.96 cM, cytoband B2-B5
• Alliance: Acadvl^tm1Vje page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98627
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene in opposite orientation of endogenous transcription replaced exons 1 through 7. Northern blot of heart and muscle from mutants confirmed complete absence of mRNA. (J:98627)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acadvl Mutation: 28 strains or lines available

References

• Original: J:98627 Exil VJ, et al., Very-long-chain acyl-coenzyme a dehydrogenase deficiency in mice. Circ Res. 2003 Sep 5;93(5):448-55
• All: 22 reference(s)