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Acadvltm1Vje
Targeted Allele Detail
Nomenclature
Symbol: Acadvltm1Vje
Name: acyl-Coenzyme A dehydrogenase, very long chain; targeted mutation 1, Vernat J Exil
MGI ID: MGI:3606688
Synonyms: VLCAD-
Gene: Acadvl  Location: Chr11:70010183-70015411 bp, - strand  Genetic Position: Chr11, 42.96 cM, cytoband B2-B5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:98627
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance gene in opposite orientation of endogenous transcription replaced exons 1 through 7. Northern blot of heart and muscle from mutants confirmed complete absence of mRNA. (J:98627)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Acadvl Mutation:  14 strains or lines available
References
Original:  J:98627 Exil VJ, et al., Very-long-chain acyl-coenzyme a dehydrogenase deficiency in mice. Circ Res. 2003 Sep 5;93(5):448-55
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory