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Targeted Allele Detail
Symbol: Rxrbtm1Mma
Name: retinoid X receptor beta; targeted mutation 1, Manuel Mark
MGI ID: MGI:3606210
Synonyms: Rxrbaf2, Rxrbaf2o
Gene: Rxrb  Location: Chr17:34031812-34038393 bp, + strand  Genetic Position: Chr17, 17.98 cM
Rxratm1Ipc/Rxratm4Ipc Rxrbtm1Mma/Rxrbtm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0 mice develop alopecia but no skin inflammation while Rxratm4Ipc/Rxratm4Ipc Rxrbtm1Pcn/Rxrbtm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0 mice show both hair loss and skin inflammation

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:101966
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector was designed to replace the 46 nucleotides encoding alpha-helix 12 that contains the AF-2 AD core with 3 stop codons, thereby creating a protein truncated at amino acid 502. Northern blot demonstrated expression of a truncated mRNA. (J:101966)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rxrb Mutation:  14 strains or lines available
Original:  J:101966 Mascrez B, et al., Ligand-dependent contribution of RXRbeta to cholesterol homeostasis in Sertoli cells. EMBO Rep. 2004 Mar;5(3):285-90
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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