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Spontaneous Allele Detail
Symbol: Grm6nob3
Name: glutamate receptor, metabotropic 6; no b wave 3
MGI ID: MGI:3605835
Gene: Grm6  Location: Chr11:50741512-50757035 bp, + strand  Genetic Position: Chr11, 30.93 cM
Strain of Origin:  C57BL/10
Allele Type:    Spontaneous (Null/knockout)
Mutation:    Single point mutation
Mutation detailsA C-to-T transition occured spontaneously in intron 1. This results in a new splice donor site (G-GT from G-GC), which alters splicing and, together with an upstream cryptic splice donor CAG, inserts a new 65 bp exon between exons 1 and 2. This leads to a frame shift and premature termination. The absence of protein expression was confirmed by immunohistochemistry on the outer plexiform layer. (J:152828)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Grm6 Mutation:  40 strains or lines available
Original:  J:152828 Maddox DM, et al., Allelic variance between GRM6 mutants, Grm6nob3 and Grm6nob4 results in differences in retinal ganglion cell visual responses. J Physiol. 2008 Sep 15;586(Pt 18):4409-24
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory