Apc^tm4Mmt
Targeted Allele Detail

Summary

• Symbol: Apc^tm4Mmt
• Name: APC, WNT signaling pathway regulator; targeted mutation 4, Makoto M Taketo
• MGI ID: MGI:3605472
• Synonyms: Apc^neoF
• Gene: Apc Location: Chr18:34353977-34455605 bp, + strand Genetic Position: Chr18, 18.53 cM
• Alliance: Apc^tm4Mmt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101604
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Insertion
• Mutation details: A neomycin resistance gene was inserted into intron 13 in the same orientation as transcription. This hypomorphic allele expresses protein at levels reduced to 10% of the wild-type. (J:101604)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apc Mutation: 154 strains or lines available

References

• Original: J:101604 Li Q, et al., The threshold level of adenomatous polyposis coli protein for mouse intestinal tumorigenesis. Cancer Res. 2005 Oct 1;65(19):8622-7
• All: 2 reference(s)