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Targeted Allele Detail
Symbol: Icam1tm1Alb
Name: intercellular adhesion molecule 1; targeted mutation 1, Arthur L Beaudet
MGI ID: MGI:3605161
Synonyms: ICAM-1-, ICAM-1null
Gene: Icam1  Location: Chr9:21015960-21028797 bp, + strand  Genetic Position: Chr9, 7.69 cM
Germline Transmission:  Earliest citation of germline transmission: J:100242
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe entire coding region was deleted, from the BamHI site 5' of exon 1 to the SalI site 3' of the poly(A) site in exon 7, and replaced by a puromycin resistance cassette transcribed in the opposite direction. (J:100242, J:142629)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Icam1 Mutation:  15 strains or lines available
Original:  J:100242 Dunne JL, et al., Mac-1, but not LFA-1, uses intercellular adhesion molecule-1 to mediate slow leukocyte rolling in TNF-alpha-induced inflammation. J Immunol. 2003 Dec 1;171(11):6105-11
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.06
The Jackson Laboratory