Asl^tm1Wjc
Targeted Allele Detail

Summary

• Symbol: Asl^tm1Wjc
• Name: argininosuccinate lyase; targeted mutation 1, William J Craigen
• MGI ID: MGI:3604881
• Synonyms: AL^-
• Gene: Asl Location: Chr5:130040099-130053222 bp, - strand Genetic Position: Chr5, 68.37 cM
• Alliance: Asl^tm1Wjc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101658
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 8 and 9 were replaced with a neomycin resistance cassette, creating an out of frame transcript beginning at exon 10. (J:101658)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Asl Mutation: 24 strains or lines available

References

• Original: J:101658 Reid Sutton V, et al., A mouse model of argininosuccinic aciduria: biochemical characterization. Mol Genet Metab. 2003 Jan;78(1):11-6
• All: 2 reference(s)