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Npm1tm2Ppp
Targeted Allele Detail
Nomenclature
Symbol: Npm1tm2Ppp
Name: nucleophosmin 1; targeted mutation 2, Pier Paolo Pandolfi
MGI ID: MGI:3604808
Synonyms: Npmhyp
Gene: Npm1  Location: Chr11:33152287-33163206 bp, - strand  Genetic Position: Chr11, 19.21 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101494
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsAn Frt-flanked neomycin resistance cassette was inserted into intron 6. Mutant mice expressed protein at levels reduced to about 10-30% of wild-type levels. LoxP sites were inserted to flank exons 1 to 6, encompassing the inserted neo. (J:101494)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Npm1 Mutation:  16 strains or lines available
References
Original:  J:101494 Grisendi S, et al., Role of nucleophosmin in embryonic development and tumorigenesis. Nature. 2005 Sep 1;437(7055):147-53
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory