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Npm1tm1Ppp
Targeted Allele Detail
Nomenclature
Symbol: Npm1tm1Ppp
Name: nucleophosmin 1; targeted mutation 1, Pier Paolo Pandolfi
MGI ID: MGI:3604807
Synonyms: Npm-
Gene: Npm1  Location: Chr11:33152287-33163206 bp, - strand  Genetic Position: Chr11, 19.21 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101494
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector containing GFP was inserted in-frame with exon 2 at the upstream end, with a modified ACN cassette containing a self-excising neo, resulting in the removal of exons 2-7. GFP was demonstrated to express in the same manner as the endogenous protein. (J:101494)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Npm1 Mutation:  17 strains or lines available
Notes
Heterozygous mice exhibit phenotypic similarity to human myelodysplastic syndromes (MDS).

References
Original:  J:101494 Grisendi S, et al., Role of nucleophosmin in embryonic development and tumorigenesis. Nature. 2005 Sep 1;437(7055):147-53
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/13/2015
MGI 5.21
The Jackson Laboratory