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G3bp1tm1Tazi
Targeted Allele Detail
Nomenclature
Symbol: G3bp1tm1Tazi
Name: GTPase activating protein (SH3 domain) binding protein 1; targeted mutation 1, Jamal Tazi
MGI ID: MGI:3604716
Synonyms: G3BP-
Gene: G3bp1  Location: Chr11:55469752-55500888 bp, + strand  Genetic Position: Chr11, 33.09 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101358
Parent Cell Line:  CK35 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe locus was disrupted by the insertion of a promoterless beta-geo cassette into exon 2 at the ATG. Sequence from exons 2 and 3 were removed. Western blot confirmed successful ablation of the endogenous protein, and successful expression of betagal in mutant embryos. (J:101358)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 31 assay results
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any G3bp1 Mutation:  29 strains or lines available
References
Original:  J:101358 Zekri L, et al., Control of fetal growth and neonatal survival by the RasGAP-associated endoribonuclease G3BP. Mol Cell Biol. 2005 Oct;25(19):8703-16
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory