Itpr3^tm1Kmik
Targeted Allele Detail

Summary

• Symbol: Itpr3^tm1Kmik
• Name: inositol 1,4,5-triphosphate receptor 3; targeted mutation 1, Katsuhiko Mikoshiba
• MGI ID: MGI:3604625
• Synonyms: IP3R3^-, IP3R3KO, IP3R3 KO
• Gene: Itpr3 Location: Chr17:27276278-27341197 bp, + strand Genetic Position: Chr17, 13.68 cM
• Alliance: Itpr3^tm1Kmik page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101380
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first coding exon was disrupted downstream of the ATG by replacement of sequence with a neomycin resistance gene. Immunoblot confirmed absence of protein in mutants. (J:101380)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Itpr3 Mutation: 174 strains or lines available

References

• Original: J:101380 Futatsugi A, et al., IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism. Science. 2005 Sep 30;309(5744):2232-4
• All: 18 reference(s)