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Itpr2tm1Kmik
Targeted Allele Detail
Nomenclature
Symbol: Itpr2tm1Kmik
Name: inositol 1,4,5-triphosphate receptor 2; targeted mutation 1, Katsuhiko Mikoshiba
MGI ID: MGI:3604623
Synonyms: IP3R2-
Gene: Itpr2  Location: Chr6:146108299-146502223 bp, - strand  Genetic Position: Chr6, 77.7 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101380
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe first exon coding the first six amino acids was fused in-frame to the lacZ gene with an NLS. Immunoblot failed to detect protein in mutants. (J:101380)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Itpr2 Mutation:  9 strains or lines available
References
Original:  J:101380 Futatsugi A, et al., IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism. Science. 2005 Sep 30;309(5744):2232-4
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory