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Scn11atm1Dgen
Targeted Allele Detail
Summary
Symbol: Scn11atm1Dgen
Name: sodium channel, voltage-gated, type XI, alpha; targeted mutation 1, Deltagen
MGI ID: MGI:3604572
Synonyms: Nav1.9-, SCN11A-
Gene: Scn11a  Location: Chr9:119582829-119654522 bp, - strand  Genetic Position: Chr9, 71.33 cM, cytoband F3-F4
Alliance: Scn11atm1Dgen page
Mutation
origin
Mutant Cell Line:  3268
Germline Transmission:  Earliest citation of germline transmission: J:101679
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Project Collection: Deltagen
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn IRES-lacZ-neo cassette was inserted to replace 174 bp encompassing exon 3 and parts of exons 2 and 4, and encoding the first and second membrane-spanning segments of domain I. While RT-PCR analysis detects a gene transcript in most tissues analyzed, beta-galactosidase expression from this allele is not detectable in any tissues or organs. (J:99870)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 51 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Scn11a Mutation:  53 strains or lines available
Notes
See also, data as provided by Deltagen, Inc.
References
Original:  J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005;
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory