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Drd5tm1Dgen
Targeted Allele Detail
Nomenclature
Symbol: Drd5tm1Dgen
Name: dopamine receptor D5; targeted mutation 1, Deltagen
MGI ID: MGI:3604549
Gene: Drd5  Location: Chr5:38319367-38322518 bp, + strand  Genetic Position: Chr5, 20.4 cM
Mutation
origin
Mutant Cell Line:  1853
Germline Transmission:  Earliest citation of germline transmission: J:101679
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Project Collection: Deltagen
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. RT-PCR analysis detects a high level of gene transcript in whole brain, cortex, subcortical region, brainstem, olfactory bulb, spinal cord, eye, spleen and testis and low levels in cerebellum, thymus, skin, urinary bladder, pituitary gland, epididymis, coagulating gland, prostate gland, and white fat. However, beta-galactosidase expression from this allele is faintly detectable in only in a few follicles in the ovary. (J:101679)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 50 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Drd5 Mutation:  24 strains or lines available
Notes
See also, data as provided by Deltagen, Inc.
References
Original:  J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory