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Targeted Allele Detail
Symbol: Chrna2tm1Dgen
Name: cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal); targeted mutation 1, Deltagen
MGI ID: MGI:3604548
Gene: Chrna2  Location: Chr14:66372488-66390397 bp, + strand  Genetic Position: Chr14, 34.36 cM
Alliance: Chrna2tm1Dgen page
Mutant Cell Line:  5414
Germline Transmission:  Earliest citation of germline transmission: J:101679
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Project Collection: Deltagen
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsA bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. While RT-PCR analysis detects a gene transcript in all tissues tested, strong beta-galactosidase expression from this allele is detectable only in a small region of the whole mount brainstem. No expression was detected on coronal sections of brain. Moderate staining was observed in the ovarian stroma.
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 36 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Chrna2 Mutation:  25 strains or lines available
See also, data as provided by Deltagen, Inc.
Original:  J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory