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Gene trapped Allele Detail
Symbol: Scn3aGt(OST52130)Lex
Name: sodium channel, voltage-gated, type III, alpha; gene trap OST52130, Lexicon Genetics
MGI ID: MGI:3604522
Synonyms: Scn3aGt701Lex, Scn3aHyp
Gene: Scn3a  Location: Chr2:65287462-65397935 bp, - strand  Genetic Position: Chr2, 38.55 cM
Mutant Cell Line:  OST52130
Germline Transmission:  Earliest citation of germline transmission: J:103485
Parent Cell Line:  Lex-1 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Project Collection: Lexicon
Allele Type:    Gene trapped (Hypomorph)
Mutation:    Insertion of gene trap vector
Mutation detailsRetroviral insertion occurs just upstream of the first coding exon. PCR analysis on whole brain samples from one-day old (P1) WT, heterozygous and homozygous littermates showed approximately 70% and nearly 100% reduction of mRNA expression from this allele in the brains of heterozygous and homozygous mutants, respectively. Western blotting indicated that protein expression in the brains of P1 heterozygous and homozygous mutants from this allele, compared to WT, was reduced by approximately 35% (p < 0.05) and 60% (p < 0.001), respectively, suggesting that the gene trap mutation is hypomorphic. (J:103485, J:250111)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Scn3a Mutation:  72 strains or lines available
See also, data as provided by Lexicon Genetics, Inc.
Original:  J:103485 Lexicon Genetics Inc, NIH initiative supporting placement of Lexicon Genetics, Inc. mice into public repositories. MGI Direct Data Submission. 2005;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.20
The Jackson Laboratory