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Fzd10tm1Dgen
Targeted Allele Detail
Nomenclature
Symbol: Fzd10tm1Dgen
Name: frizzled class receptor 10; targeted mutation 1, Deltagen
MGI ID: MGI:3604499
Gene: Fzd10  Location: Chr5:128600844-128604093 bp, + strand  Genetic Position: Chr5, 67.67 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101679
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Project Collection: Deltagen
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Disruption caused by insertion of vector
 
Mutation detailsA bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. RT-PCR analysis detects a high level of gene transcript in urinary bladder, adrenal gland and uterus, moderate levels in whole brain, cortex, subcortical region, cerebellum, brainstem, spinal cord, eye, thymus, lymph nodes, skin, gallbladder, pituitary gland, salivary gland, tongue, stomach, epididymis, coagulating gland, prostate gland, ovary and white fat and low levels in olfactory bulb, Harderian glands, lung, liver, kidney, spleen, skeletal muscle, small intestine, large intestine, cecum, testis and seminal vesicle. Beta-galactosidase expression from this allele is detectable in brain, spinal cord, eyes, kidney, skin, prostate gland, uterus and cervix. Most striking lacZ expression was detected in the central nervous system and cervical epithelium. In the brain very strong staining was observed in different structures, including brainstem, thalamus and ventricles. Very strong, scattered staining was also detected throughout the spinal cord. Staining was observed in different cell and tissue types, including neurons, epithelium, smooth muscle and blood vessels.
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 60 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fzd10 Mutation:  12 strains or lines available
Notes
See also, data as provided by Deltagen, Inc.
References
Original:  J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory