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Targeted Allele Detail
Symbol: Adamts5tm1Dgen
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2); targeted mutation 1, Deltagen
MGI ID: MGI:3604488
Synonyms: Adamts5deltacat, ts5-
Gene: Adamts5  Location: Chr16:85655045-85698013 bp, - strand  Genetic Position: Chr16, 48.34 cM
Alliance: Adamts5tm1Dgen page
Mutant Cell Line:  8491
Germline Transmission:  Earliest citation of germline transmission: J:101679
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Project Collection: Deltagen
Allele Type:    Targeted (Modified regulatory region, Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAn IRES-lacZ gene was inserted into and replaced 134 nucleotides of exon 2. The deleted region includes sequences encoding the catalytic active site as well as most of the putative muscle regulatory factor-binding enhancer. The highest levels of RNA transcripts are detectable in pancreas, adrenal gland and white fat. Moderate levels of RNA transcripts are detectable in: olfactory bulb, heart, lung, thymus, skin, gallbladder, testis, epididymis and coagulating gland. Lower levels of RNA transcripts are also detectable in: whole brain, cortex, subcortical region, cerebellum, brainstem, spinal cord, eye, Harderian glands, liver, kidney, spleen, lymph nodes, bone marrow, urinary bladder, pituitary gland, salivary gland, skeletal muscle, tongue, stomach, small intestine, large intestine, cecum, seminal vesicle, prostate gland and uterus. LacZ expression was detected in all organs examined. (J:148803)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 316 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adamts5 Mutation:  33 strains or lines available
See also, data as provided by Deltagen, Inc.
Original:  J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005;
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory