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Gria4tm1Dgen
Targeted Allele Detail
Nomenclature
Symbol: Gria4tm1Dgen
Name: glutamate receptor, ionotropic, AMPA4 (alpha 4); targeted mutation 1, Deltagen
MGI ID: MGI:3604485
Synonyms: Gria4KO
Gene: Gria4  Location: Chr9:4417896-4796234 bp, - strand  Genetic Position: Chr9, 2.46 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101679
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Project Collection: Deltagen
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsGenotyping (long range PCR and genomic sequencing) for this allele revealed that the 5' half of intron 3-lacZ-neo-intron 3 construct inserted into Gria4 intron 3 resulting in truncation of most of the lacZ gene and some of intron 3, instead of the intended homologous replacement of Gria4 exon 3 with a lacZ-neo cassette. No Gria4 RNA was detected in the brain by RT-PCR.
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 32 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Gria4 Mutation:  35 strains or lines available
Notes
See also, data as provided by Deltagen, Inc.
References
Original:  J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005;
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory